Effects of Other Drugs on BiCNU: Cimetidine: Greater myelosuppression (e.g., leukopenia and neutropenia) has been reported when oral cimetidine has been coadministered with carmustine. Consider alternative drugs to cimetidine.
Phenobarbital: Phenobarbital induces the metabolism of carmustine and may compromise antitumor activity of BiCNU.
Consider alternative drugs to phenobarbital.
Effects of BiCNU on Other Drugs: Phenytoin: BiCNU when coadministered with phenytoin may reduce phenytoin serum concentrations. Consider alternative drugs to phenytoin.