Active upper GI problems eg, dysphagia, oesophageal disease, gastritis, duodenitis, ulcers or recent history (1 yr) of major GI disease eg, peptic ulcer or active GI bleeding or surgery of the upper GIT other than pyloroplasty. Potential risks in patients w/ Barrett's oesophagus. Discontinue use if signs or symptoms of oesophageal irritation occurs. Osteonecrosis of the jaw associated w/ tooth extraction &/or local infection (including osteomyelitis). Dental examination w/ appropriate preventive dentistry should be considered prior to treatment in patients w/ poor dental status & avoid invasive dental procedures. Maintain good oral hygiene, receive routine dental check-ups & report any oral symptoms (eg, dental mobility, pain or swelling). Bone, joint, &/or muscle pain. Atypical subtrochanteric & diaphyseal femoral fractures have been reported in patients receiving long-term treatment for osteoporosis. Possible risk factors for osteonecrosis of the external auditory canal include steroid use & chemotherapy &/or local risk factors eg, infection or trauma. Hypocalcaemia must be corrected before initiating therapy. Adequate Ca & vit D intake particularly in patients receiving glucocorticoids. May affect the ability to drive or operate machinery. Patients on a controlled Na diet. Not recommended for patients w/ renal impairment (GFR <35 mL/min). Do not use during pregnancy & lactation. Not recommended for use in Childn <18 yr.