Brivaracetam is used together with other medicines to treat epilepsy (known as fits or seizures).
Take Brivaracetam exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
Brivaracetam is available as a tablet or an oral solution.
If you are given the tablet, swallow it whole with a glass of water. Do not chew or crush the tablet.
If you are given the oral solution, use the oral dosing syringe supplied with each bottle to measure out your dose. Refer to the package insert for directions on how the syringe should be used. The oral solution may be taken on its own or you may mix it with water or juice. Once it is mixed, drink it immediately.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your condition and response to the medication.
Brivaracetam must be taken regularly for it to be effective. Continue taking it even when you feel better. Do not stop taking this medicine unless instructed otherwise, as stopping it suddenly may worsen your condition. Your doctor will gradually reduce the dose before stopping it or changing it to another medicine.
If you missed one dose or more, take one single dose as soon as you remember and take the next dose at your normal dosing schedule.
DO NOT double a dose to make up for the missed dose.
If you often forget to take your medicine, let your doctor and pharmacist know.
Inform your doctor if you have liver disease.
This medicine is not recommended for patients with severe kidney disease undergoing dialysis.
Let your doctor know if you are pregnant or breastfeeding.
Be sure to check with your doctor or pharmacist before giving Brivaracetam to a child.
Some genetic traits can affect this medicine’s efficacy. Individuals who are poor metaboliser of CYP2C19 may experience enhanced side effects of Brivaracetam (e.g. dizziness, tiredness, nausea, sleepiness). Although not routinely done, your doctor may advise you to undergo genetic testing to check if this medicine is best suited for you. If you know you have this gene type, inform your doctor.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Your doctor may need to do routine blood tests (e.g. complete blood count, liver and kidney function) while you are being treated with Brivaracetam. He will advise you about how often you need to have these tests.
- Monitoring of signs of depression, suicidal thoughts or attempts may also be needed.
Brivaracetam may cause dizziness, drowsiness, or balance and coordination problems. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects may include any of the following: cough, common cold, flu, nausea, vomiting, constipation, decreased appetite, tiredness, dizziness with sensations of spinning, and difficulty sleeping.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- rashes, breathlessness, swollen eyes, mouth or throat
- chest pain or tightness, difficulty breathing
- having thoughts of self-harm
- unusual changes in mood or behaviour (being too depressed, agitated, or aggressive)
- seeing, hearing or feeling things that are not existent
Brivaracetam may cause the level of your white blood cells to drop.
White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines for epilepsy (fits or seizures) e.g. phenobarbital, carbamazepine, phenytoin
- medicines that reduce stomach acid production e.g. omeprazole, lansoprazole
- rifampicin (medicine to treat an infection known as tuberculosis)
- fluvoxamine (medicine to treat depression)
- fluconazole (medicine to treat fungal infections)
- diazepam (medicine for sleep disorder or anxiety)
- efavirenz (medicine for HIV infection)
- St John’s wort (herbal medicine)
This list does not include all medicines that may interact with Brivaracetam.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
The oral solution should be used within 5 months after opening. Do not freeze.
Medicines must not be used past the expiry date.