Steward Cross
Concise Prescribing Info
In combination w/ cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Dosage/Direction for Use
Adult 0.8 mg/kg IV via a central venous catheter as a 2-hr infusion 6 hrly for 4 consecutive days (total: 16 doses).
Special Precautions
Prolonged myelosuppression. Monitor hematologic status & blood count. History of seizure disorder or head trauma or patients on other potentially epileptogenic drugs. Prior radiation therapy, ≥3 cycles of chemotherapy or prior progenitor cell transplant may be at increased risk of hepatic veno-occlusive disease. Monitor for signs & symptoms, promptly evaluate & treat if cardiac tamponade is suspected. Bronchopulmonary dysplasia w/ pulmonary fibrosis (ave onset of symptoms is 4 yr after therapy); cellular dysplasia. Monitor for signs of local or systemic infection or bleeding. Males & females of reproductive potential must use effective contraception during & after treatment. Pregnancy & lactation. Childn.
Adverse Reactions
Fever, headache, asthenia, chills, pain, general edema, allergic reaction, chest pain, inflammation at inj site, back pain; tachycardia, HTN, thrombosis, vasodilation; nausea, stomatitis, vomiting, anorexia, diarrhea, abdominal pain, dyspepsia, constipation, dry mouth, rectal disorder, abdominal enlargement; hypomagnesemia, hyperglycemia, hypokalemia, hypocalcemia, hyperbilirubinemia, edema. SGPT elevation, increased creatinine; insomnia, anxiety, dizziness, depression; rhinitis, lung disorder, cough, epistaxis, dyspnea; rash, pruritus.
Drug Interactions
Decreased clearance w/ itraconazole & acetaminophen. Increased clearance w/ phenytoin. Increased plasma levels w/ metronidazole.
ATC Classification
L01AB01 - busulfan ; Belongs to the class of alkylating agents, alkyl sulfonates. Used in the treatment of cancer.
Busulfex inj 6 mg/mL
10 mL x 1's
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