Casodex

Casodex Adverse Reactions

bicalutamide

Manufacturer:

AstraZeneca

Distributor:

Zuellig Pharma
Full Prescribing Info
Adverse Reactions
Increased PT/INR: Amounts of Coumarin anticoagulants interacting with Casodex have been reported in post-marketing surveillance (see Precautions and Interactions).
50-mg:
Casodex in general, has been well tolerated with few withdrawals due to adverse events. (See Table 3.)

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Rare cardiovascular effects such as angina, heart failure, conduction defects including PR and QT interval prolongations, arrhythmias and non-specific ECG changes have been observed.
Thrombocytopenia has been reported uncommonly.
In addition, the following adverse experiences were reported in clinical trials (as possible adverse drug reactions in the opinion of investigating clinicians, with a frequency of ≥1%) during treatment with Casodex plus an LHRH analogue. No causal relationship of these experiences to drug treatment has been made and some of the experiences reported are those that commonly occur in elderly patients: Cardiovascular system: heart failure.
Gastrointestinal system: anorexia, dry mouth, dyspepsia, constipation, flatulence.
Central nervous system: dizziness, insomnia, somnolence, decreased libido.
Respiratory system: dyspnoea.
Urogenital: impotence, nocturia.
Haematological: anaemia.
Skin and appendages: alopecia, rash, sweating, hirsutism.
Metabolic and nutritional: diabetes mellitus, hyperglycaemia, oedema, weight gain, weight loss.
Whole body: abdominal pain, chest pain, headache, pain, pelvic pain, chills.
150-mg: The frequencies of adverse events are ranked according to the following: Very common (≥10%); Common (≥1% and <10%); Uncommon (≥0.1% and <1%); Rare (≥0.01% and <0.1%). (See Table 4.)

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Rare cardiovascular effects such as angina, heart failure, conduction defects including PR and QT interval prolongations, arrhythmias and non-specific ECG changes have been observed.
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