Oral Skin and skin structure infections, Urinary tract infections
Adult: Usual dose: 1 or 2 g daily as a single or in 2 divided doses. Individualise dosage based on the susceptibility of pathogens, severity of infection, and clinical status of the patient. Consideration must be given to local treatment guidelines on the appropriate use of antibacterials. Child: ≥6 years Recommended dose: <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses. Max: 100 mg/kg daily. >40 kg: Same as adult dose. Consideration must be given to local treatment guidelines on the appropriate use of antibacterials.
Oral Streptococcal pharyngitis, Tonsillitis
Adult: For cases caused by susceptible strains of Streptococcus pyogenes (group A β-haemolytic streptococci): 1 g once daily or 500 mg bid for at least 10 days. Consideration must be given to local treatment guidelines on the appropriate use of antibacterials. Child: Recommended dose: <40 kg: 30 mg/kg daily as a single or in 2 divided doses for at least 10 days. Max: 100 mg/kg daily. >40 kg: Same as adult dose.
Patient on haemodialysis: Give an additional 0.5-1 g dose at the end of each dialysis session. CrCl ≤10 mL/min/1.73 m2: Initially, 1 g as a single dose, then 0.5-1 g every 36 hours. CrCl 11-25 mL/min/1.73 m2: Initially, 1 g as a single dose, then 0.5-1 g every 24 hours. CrCl 26-50 mL/min/1.73 m2: Initially, 1 g as a single dose, then 0.5-1 g every 12 hours.
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Powder for oral susp: Tap the bottle to lightly loosen the powder, then add the appropriate amount of water as specified on the packaging. Shake the bottle well after each addition until suspended.
Hypersensitivity to cefadroxil or other cephalosporins.
Patient with history of hypersensitivity to penicillins or any other β-lactam drugs, severe allergy or asthma; history of gastrointestinal disease, especially colitis. Renal impairment. Pregnancy and lactation.
Significant: Hypersensitivity reactions, including anaphylaxis; Clostridium difficile-associated diarrhoea. Blood and lymphatic system disorders: Rarely, eosinophilia, neutropenia, thrombocytopenia, agranulocytosis. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, dyspepsia, abdominal pain, glossitis. General disorders and administration site conditions: Rarely, fever. Immune system disorders: Rarely, serum sickness-like reaction, angioneurotic oedema. Investigations: Rarely, slightly elevated AST and ALT. Musculoskeletal and connective tissue disorders: Rarely, arthralgia. Skin and subcutaneous tissue disorders: Rash, pruritus, allergic exanthema, urticaria. Potentially Fatal: Pseudomembranous colitis.
Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Monitor renal function test, LFTs and blood count frequently on long-term use; signs and symptoms of anaphylaxis during 1st dose.
Symptoms: Nausea, hyperreflexia, extrapyramidal symptoms, hallucinations, clouded consciousness or even coma, and renal function impairment. Management: Immediately induce vomiting or perform gastric lavage. Consider haemodialysis if needed. Monitor renal function, and correct water and electrolyte balance if necessary.
May cause an antagonistic effect with bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol). May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May cause haemorrhagic complications with prolonged use of anticoagulant or thrombocyte inhibitors. May increase plasma concentration with probenecid. May decrease bioavailability with colestyramine.
Positive direct Coombs’ test. May result in false-positive reaction for urine glucose using cupric sulfate (Benedict’s solution, Fehling’s solution); false-positive serum or urine creatinine with Jaffé reaction.
Description: Cefadroxil is a 1st generation oral cephalosporin. It binds to 1 or more of the penicillin-binding proteins (PBPs) which in turn blocks the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thereby inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial lysis. Pharmacokinetics: Absorption: Rapidly and almost completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1-2 hours. Distribution: Widely distributed into body tissues and fluids. Crosses the placenta and enters breast milk. Volume of distribution: 0.31 L/kg. Plasma protein binding: Approx 20%. Excretion: Via urine (>90% as unchanged drug within 24 hours). Elimination half-life: 1-2 hours; 20-24 hours (patient with renal failure).
Store between 20-25°C. Reconstituted powder for susp: Store between 2-8°C. Discard unused portion after 14 days.
J01DB05 - cefadroxil ; Belongs to the class of first-generation cephalosporins. Used in the systemic treatment of infections.
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