Zuellig Pharma
Concise Prescribing Info
Varenicline tartrate
Aid to smoking cessation treatment.
Dosage/Direction for Use
Adult 1 mg bd following a 1-wk titration as: 0.5 mg once daily on days 1-3, 0.5 mg bd on days 4-7 & 1 mg bd on day 8 until the end of treatment. Treatment duration: 12 wk. Maintenance of abstinence: Additional 12-wk treatment course w/ 1 mg bd. Consider a gradual approach to quitting smoking in patients who are not able or willing to quit abruptly; reduce smoking during the 1st 12 wk of treatment & quit by the end of treatment period; continue treatment for an additional 12 wk for a total of 24 wk of treatment. Make another treatment attempt once factors contributing to failed attempts are identified & addressed, in patients who do not succeed in stopping smoking during 12 wk of initial therapy, or who relapsed after treatment. Patients who cannot tolerate adverse effects may have the dose lowered temporarily or permanently. Severe renal impairment Initially 0.5 mg once daily for 1st 3 days then increased to 1 mg once daily.
May be taken with or without food.
Special Precautions
Serious neuropsychiatric symptoms & suicidality in patients w/ or w/o preexisting psychiatric disease. Discontinue in case of somnambulism; angioedema & hypersensitivity reactions; severe skin reactions including Stevens-Johnson syndrome & erythema multiforme; new or worsening symptoms of CV disease. Consider dose reduction in patients w/ intolerable nausea. Patients w/ physiological changes resulting from smoking cessation; history of seizures or other conditions that potentially lower the seizure threshold. May impair ability to drive or operate machinery. Pregnancy & lactation. Not recommended in childn <18 yr.
Adverse Reactions
Nasopharyngitis; abnormal dreams, insomnia; headache; nausea. Bronchitis, sinusitis; increased wt, decreased or increased appetite; somnolence, dizziness, dysgeusia; dyspnoea, cough; GERD, vomiting, constipation, diarrhoea, abdominal distention, abdominal pain, toothache, dyspepsia, flatulence, dry mouth; rash, pruritus; arthralgia, myalgia, back pain; chest pain, fatigue; abnormal liver function test.
Drug Interactions
Increased systemic exposure w/ cimetidine. May increase intoxicating effects of alcohol. Greater incidence of nausea, headache, vomiting, dizziness, dyspepsia & fatigue w/ nicotine replacement therapy.
ATC Classification
N07BA03 - varenicline ; Belongs to the class of drugs used in the management of nicotine dependence.
Champix starter pack
Champix FC tab 1 mg
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