Combivent

Combivent

ipratropium bromide + salbutamol

Manufacturer:

Boehringer Ingelheim

Distributor:

DKSH
Concise Prescribing Info
Contents
Per unit dose vial (UDV) Ipratropium Br anhydrous 0.5 mg, salbutamol (as sulphate) 2.5 mg
Indications/Uses
Management of reversible bronchospasm associated w/ obstructive airway diseases in patients who require more than a single bronchodilator.
Dosage/Direction for Use
Adult (including elderly) Acute attacks 1 unit dose vial. Severe cases May require 2nd unit-dose vial to be administered. Maintenance: 1 unit dose vial tds or qds.
Contraindications
Hypersensitivity to atropine or its derivatives. Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.
Special Precautions
Immediate hypersensitivity reactions. Immediately discontinue if paradoxical bronchospasm occurs. Patients predisposed to glaucoma, insufficiently controlled DM, recent MI, severe organic heart or vascular disorders, patients w/ underlying severe heart disease, hyperthyroidism, phaeochromocytoma, risk of narrow-angle glaucoma, prostatic hypertrophy or bladder neck obstruction, hypoxia, cystic fibrosis. Acute, rapidly worsening dyspnoea. Patients w/ hepatic or renal insufficiency. May affect ability to drive or operate machinery. Pregnancy (especially 1st trimester) & lactation. Not for paed.
Adverse Reactions
Headache, throat irritation, cough, dry mouth, GI motility disorders (eg, constipation, diarrhea & vomiting), nausea & dizziness.
Drug Interactions
Increased side effects w/ xanthine derivatives, other β-adrenergics & anticholinergics. Increased β2-agonist induced hypokalaemia w/ glucocorticosteroids & diuretics. Increased susceptibility to arrhythmia w/ digoxin. Potentially serious reduction in bronchodilator effects w/ β-blockers. Enhanced β-adrenergic agonists action w/ MAOIs or TCAs. Increased susceptibility to CV effects of β-agonists w/ halogenated hydrocarbon anaesth eg, halothane, trichloroethylene & enflurane.
ATC Classification
R03AL02 - salbutamol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Form
Combivent inhalation soln
Packing/Price
(unit-dose vial) 2.5 mL x 20 × 1's ($37.4/box)
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $139 a year.
Sign up for free
Already a member? Sign in