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Concise Prescribing Info
Bisoprolol fumarate
HTN, CHD (angina pectoris), stable chronic heart failure w/ reduced systolic left ventricular function in addition to ACE inhibitors & diuretics & optionally cardiac glycosides.
Dosage/Direction for Use
HTN or angina pectoris 5 mg once daily, may be increased to 10 mg once daily. Stable chronic heart failure 1.25 mg once daily for 1 wk, if well-tolerated increase to 2.5 mg once daily for a further wk, if well-tolerated increase to 3.75 mg once daily for a further wk, if well-tolerated increase to 5 mg once daily for the following 4 wk, if well-tolerated increase to 7.5 mg once daily for the following 4 wk, if well-tolerated increase to 10 mg once daily for maintenance therapy. Max: 10 mg once daily. HTN or angina pectoris in patients w/ severe renal (CrCl <20 mL/min) or liver insufficiency Do not exceed 10 mg once daily.
May be taken with or without food: Swallow whole, do not chew/crush.
Hypersensitivity. Acute heart failure or during episodes of heart failure decompensation requiring IV inotropic therapy; cardiogenic shock, 2nd- or 3rd-degree AV block (w/o pacemaker); sick sinus syndrome; SA block; symptomatic bradycardia/hypotension; severe bronchial asthma/COPD; late stages of peripheral arterial occlusive disease & Raynaud's syndrome; untreated phaeochromocytoma, metabolic acidosis.
Special Precautions
Avoid abrupt w/drawal in patients w/ ischaemic heart disease; HTN or angina pectoris & accompanying heart failure. DM w/ large fluctuations in blood glucose values, hypoglycemia, strict fasting, ongoing desensitisation therapy, 1st-degree AV block, Prinzmetal's angina, peripheral arterial occlusive disease; IDDM, severe renal or hepatic impairment, restrictive cardiomyopathy, congenital heart disease, haemodynamically significant organic valvular disease, MI w/in 3 mth; bronchial asthma or other COPD; existing or history of psoriasis, phaeochromocytoma. May mask thyrotoxicosis symptoms. Patients on general anaesth therapy & myocardial ischemia during induction & intubation & post-op period. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn.
Adverse Reactions
Bradycardia. Worsening of preexisting heart failure (in patients w/ chronic heart failure); dizziness, headache; GI complaints eg, nausea, vomiting, diarrhoea, constipation; feeling of coldness or numbness in the extremities, hypotension especially in patients w/ heart failure; asthenia (in patients w/ chronic heart failure), fatigue.
Drug Interactions
Potentiated AV conduction time & increased -ve inotropic effect w/ class I & III anti-arrhythmics, Ca antagonists; decrease central sympathetic tonus, heart rate & cardiac output w/ centrally-acting antihypertensives (eg, clonidine, methyldopa, moxonidine, rilmenidine); risk of rebound HTN when abruptly w/drawn. May reduce hypotensive effect w/ NSAIDs. Increased risk of hypotension w/ felodipine & amlodipine, anaesth, TCAs, barbiturates, phenothiazines. Risk of bradycardia w/ parasympathomimetics, Intensified blood sugar lowering effect w/ insulin & oral diabetics. Increased BP & exacerbated intermittent claudication w/ α- & β-adrenoreceptors. Increased risk of bradycardia w/ mefloquine. Enhanced hypotensive effects & risk of hypertensive crisis w/ MAOIs.
MIMS Class
ATC Classification
C07AB07 - bisoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Concor FC tab 2.5 mg
Concor FC tab 5 mg
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