Cozaar/Cozaar XQ

Cozaar/Cozaar XQ Dosage/Direction for Use

losartan

Manufacturer:

Organon

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
Cozaar: COZAAR may be administered with or without food.
COZAAR may be administered with other antihypertensive agents.
Hypertension: The usual starting and maintenance dose is 50 mg once daily for most patients. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose to 100 mg once daily.
For patients with intravascular volume-depletion (e.g., those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered (see PRECAUTIONS).
No initial dosage adjustment is necessary for elderly patients up to 75 years of age, or for patients with mild renal impairment. For patients above 75 years of age, patients with moderate to severe renal impairment and patients on dialysis, a lower starting dose of 25mg is recommended. A lower dose should be considered for patients with a history of hepatic impairment (see PRECAUTIONS).
Reduction in the Risk of Stroke in Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is 50 mg of COZAAR once daily. A low dose of hydrochlorothiazide should be added and/or the dose of COZAAR should be increased to 100 mg once daily based on blood pressure response.
Renal Protection in Type 2 Diabetic Patients with Proteinuria: The usual starting dose is 50 mg once daily. The dose may be increased to 100 mg once daily based on blood pressure response. COZAAR may be administered with other antihypertensive agents (e.g., diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) as well as with insulin and other commonly used hypoglycemic agents (e.g., sulfonylureas, glitazones and glucosidase inhibitors).
Cozaar XQ: The recommended dose of COZAAR XQ is one tablet per day.
COZAAR XQ may be administered with or without food. It is recommended to take COZAAR XQ with water. Taking COZAAR XQ on a regular schedule (i.e. every morning) is recommended.
Dosage adjustment with each active ingredient (amlodipine or losartan) is recommended prior to starting COZAAR XQ. A patient whose blood pressure is not adequately controlled with losartan alone or amlodipine alone may be switched to combination therapy with COZAAR XQ.
COZAAR XQ 5 mg/50 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 5 mg or losartan 50 mg alone.
COZAAR XQ 5 mg/100 mg may be administered in patients whose blood pressure is not adequately controlled with losartan 100 mg or COZAAR XQ 5 mg/50 mg.
A patient co-administered with losartan and amlodipine may be switched to COZAAR XQ (fixed dose combination containing same dose of each ingredient) for compliance improvement.
Use in patients with renal impairment: No dosage adjustment is necessary in patients with mild renal impairment (i.e. creatinine clearance 20-50 mL/min). For patients with moderate to severe renal impairment (i.e. creatinine clearance <20 mL/min) or patients on dialysis, administration of COZAAR XQ is not recommended.
Use in patients with intravascular volume depletion: COZAAR XQ is not recommended for patients with intravascular volume-depletion (e.g. those treated with high-dose diuretics).
Use in patients with hepatic impairment: In cases where a lower dose of losartan (i.e. 25 mg once daily) is required for patients with a history of hepatic impairment, administration of COZAAR XQ is not recommended.
Use in the elderly: A starting dose of 25 mg of losartan once daily is recommended in elderly patients for those over 75 years, thus, administration of COZAAR XQ (combination) for initial dose is not recommended in elderly patients for those over 75 years.
Use in adolescents and children: Since safety and efficacy of COZAAR XQ in children ≤18 years of age has not been established, administration of COZAAR XQ is not recommended.
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