Discontinue immediately at the 1st appearance of signs or symptoms of any serious AR; if pain, inflammation, tendon rupture (particularly affecting the achilles tendon) occur; peripheral neuropathy symptoms. Patients w/ known risk factors for QT interval prolongation eg, congenital long QT syndrome, concomitant use of QT interval-prolonging drugs, uncorrected electrolyte imbalance, elderly, cardiac disease. Consult a specialist immediately if vision becomes impaired or any effects on the eyes are experienced; in case of sudden abdominal, chest or back pain. Increased risk of aortic aneurysm & dissection after intake, particularly in the elderly. Patients w/ positive family history of aneurysm disease, or in those diagnosed w/ preexisting aortic aneurysm &/or dissection, or in presence of other risk factors or conditions predisposing for aortic aneurysm & dissection. Increased risk of psychiatric AR; discontinue immediately if these reactions occur. Carefully monitor blood glucose; discontinue use if hypoglycaemic reaction occurs. Patients w/ or w/ a history of convulsive disorder eg, epilepsy; w/ cerebral blood flow disturbances; vein system injury. Severe renal disorder. Elderly.