Cymbalta Contraindications



Eli Lilly


Full Prescribing Info
Hypersensitivity to duloxetine or to any of the excipients.
Concomitant use of Cymbalta with non-selective, irreversible monoamine oxidase inhibitors (MAOIs) is contraindicated (see Interactions).
Patients with pre-existing liver diseases, patients with substantial alcohol use or evidence of chronic liver disease (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Cymbalta should not be used in combination with fluvoxamine, ciprofloxacin or enoxacin (i.e. potent CYP1A2 inhibitors) since the combination results in elevated plasma concentrations of Cymbalta (see Interactions).
Severe renal impairment (creatinine clearance <30 ml/min) (see Precautions).
The initiation of treatment with Cymbalta is contraindicated in patients with uncontrolled hypertension that could expose patients to a potential risk of hypertensive crisis (see Precautions and Adverse Reactions).
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