Delapril


Generic Medicine Info
Indications and Dosage
Oral
Hypertension
Adult: 15-30 mg bid.
Contraindications
Aortic stenosis or outflow tract obstruction, active or suspected renovascular disease. Pregnancy.
Special Precautions
Patient w/ history of idiopathic or hereditary angioedema, diarrhoea, water or Na depletion, peripheral vascular disease or generalised atherosclerosis, collagen vascular disorders (e.g. SLE, scleroderma). Renal impairment. Lactation.
Adverse Reactions
Hypotension, dizziness, fatigue, headache, GI disturbances, persistent dry cough and other upper resp tract symptoms, angioedema, blood disorders (e.g. neutropenia and agranulocytosis), hyperkalaemia, hyponatraemia, skin rashes.
Monitoring Parameters
Assessment of renal function prior and throughout therapy. Monitor serum K level, WBC count and presence of protein in urine regularly.
Drug Interactions
Additive hyperkalaemic effects w/ K-sparing diuretics, K supplements, other drugs that can cause hyperkalaemia (e.g. ciclosporin, indometacin).
Food Interaction
Avoid alcohol as it may potentially result to excessive hypotension.
Action
Description: Delapril inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased in plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention). It may also inhibit the degradation of bradykinin.
References
Anon. Delapril. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/03/2014.

Buckingham R (ed). ACE Inhibitors. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/03/2014.

Buckingham R (ed). Delapril. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/03/2014.

Disclaimer: This information is independently developed by MIMS based on Delapril from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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