Desonide


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% cream, oint, or lotion: Apply sparingly onto the affected areas 2-4 times daily until optimal response is achieved. Max duration of therapy: 8 wk.
Child: ≥ 2 yr Same as adult dose.

Topical/Cutaneous
Atopic dermatitis
Adult: As 0.05% foam or gel: Apply to affected area(s) bid. Max duration of therapy: 4 wk.
Child: ≥3 mth Same as adult dose.
Contraindications
Viral skin infections (e.g. vaccinia, herpes simplex), TB, acne and rosacea; ulcerated lesions.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Pruritus, pain, folliculitis, rash, peripheral oedema, pustular rash, sweating, erythema, irritation, burning, itching, dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration/atrophy, secondary infection, striae and miliaria. Adrenal suppression, manifestations of Cushing syndrome, hyperglycaemia or glycosuria, facial swelling, withdrawal syndrome, growth retardation in childn (systemic).
Patient Counseling Information
Avoid use w/ occlusive dressing. Desonide foam is flammable, do not smoke during or immediately after application.
MonitoringParameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test and urinary free cortisol test; signs and symptoms of bacterial or fungal infection.
Drug Interactions
Enhanced effect w/ other topical corticosteroids.
Action
Description: Desonide is a synthetic corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators.
Pharmacokinetics:
Absorption: Absorbed through normal skin; increased percutaneous absorption in traumatised or inflamed skin.
Metabolism: Metabolised in the liver.
Excretion: Mainly via urine; bile.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Desonide, CID=5311066, https://pubchem.ncbi.nlm.nih.gov/compound/Desonide (accessed on Jan. 20, 2020)

Storage
Store between 20-25°C.
ATC Classification
D07AB08 - desonide ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
References
Anon. Desonide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/10/2016.

Buckingham R (ed). Desonide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/10/2016.

Desonide Cream (G&W Laboratories, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/10/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Desonide (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/10/2016.

Verdeso Aerosol, Foam (Aqua Pharmaceuticals) . DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 11/10/2016.

Disclaimer: This information is independently developed by MIMS based on Desonide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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