Dexa-Gentamicin

Dexa-Gentamicin

Manufacturer:

Ursapharm

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Per mL (eye drops) Dexamethasone Na phosphate 1 mg, gentamicin sulfate 5 mg. Per g (eye oint) Dexamethasone 0.3 mg, gentamicin sulfate 5 mg
Indications/Uses
Inflammations of the anterior eye together w/ an infection caused by gentamicin-sensitive germs or in case of a risk of bacterial infection, allergic inflammations of the anterior eye (eye drops) or conjunctiva & eyelid (eye oint) w/ bacterial superinfections.
Dosage/Direction for Use
Eye drops Instill 1 drop 4-6 times daily into the conjunctival sac. Max treatment duration: 2 wk. Eye oint Apply 1 cm strip 4-6 times daily into the conjunctival sac. Max treatment duration: 2 wk.
Contraindications
Hypersensitivity. Herpes cornea superficialis. Injuries & ulcerations of the cornea. Increased IOP. TB, fungal & solely bacterial eye infections. Eye oint: Following uncomplicated removal of a corneal foreign body.
Special Precautions
Consult a doctor if patient experiences swelling & wt gain around the trunk & in the face. Adrenal gland suppression may develop after stopping a long-term or intensive treatment. Risk in childn & patients treated w/ ritonavir or cobicistat. Consider referral to an ophthalmologist if patient presents w/ symptoms eg, blurred vision or other visual disturbances. Contact lenses should not be worn during treatment. Prolonged use may give rise to overgrowth of non-susceptible microorganisms & fungi. Discontinue use if irritation or hypersensitivity develops. Cross-allergenicity among aminoglycosides or corticosteroids. Pregnancy (not to be used w/in the 1st trimester & during the later course of pregnancy) & lactation. Eye drops: Benzalkonium Cl-content may cause eye irritations or discoloration of soft contact lenses. Childn <8 yr. Eye oint: May retard corneal healing. Wool fat content may cause local skin irritations (eg, contact dermatitis). Do not drive, operate machines or work w/o stable footing shortly after application. Childn <6 yr.
Adverse Reactions
Potentially, allergic reactions, temporary light burning sensation in the eye; may increase IOP w/ prolonged use, irreversible lens opacity in childn; herpes simplex keratitis, corneal perforation in an existing inflammation, fungal infections, aggravation of corneal bacterial infection, upper eyelid droping, pupil dilatation; wound healing disorders (after corneal injuries); hypersensitive reactions w/ itching, oedema or eczema of the eyelid; (for eye drops only) cloudy patches on the cornea due to Ca build-up during treatment in some patients w/ severe corneal damage.
Drug Interactions
May cause an additional IOP increase in concomitant use w/ atropine & other anticholinergics. May cause visible precipitates in the conjunctival sac w/ amphotericin B, heparin, sulfadiazine, cephalotin & cloxacillin. May increase dexamethasone blood levels in concomitant use w/ ritonavir or cobicistat.
MIMS Class
Eye Antiseptics with Corticosteroids
ATC Classification
R01AD53 - dexamethasone, combinations ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
Presentation/Packing
Form
Dexa-Gentamicin eye drops
Packing/Price
5 mL x 1's
Form
Dexa-Gentamicin eye oint
Packing/Price
2.5 g x 1's
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