Concise Prescribing Info
Clomiphene citrate
Ovulatory failure in women desiring pregnancy. Indicated only for patients in whom ovulatory dysfunction is demonstrated.
Dosage/Direction for Use
Adult 1st course: 50 mg (1 tab) daily for 5 days, started at any time in patient w/o recent uterine bleeding. If progestin-induced bleeding is planned or if spontaneous uterine bleeding occurs before therapy, start 1st course on or about the 5th day of the cycle. 2nd course: 100 mg daily for 5 days, if ovulation does not occur after 1st course of therapy. Start as early as 30 days after the previous course.
May be taken with or without food.
Hypersensitivity. Liver disease or history of liver dysfunction; hormone-dependent tumours or abnormal uterine bleeding of undetermined origin; presence of ovarian cyst other than polycystic ovary. Pregnancy.
Special Precautions
Ineffective in patients w/ primary pituitary or primary ovarian failure. Not a substitute for specific treatment of other causes of ovulatory failure eg, thyroid or adrenal disorders. Not 1st line treatment for low wt related amenorrhoea, w/ infertility, & has no value if a high FSH blood level is observed following an early menopause. Risk of ovarian hyperstimulation syndrome; visual symptoms eg, spots or flashes (scintillating scotomata); hypertriglyceridemia; pregnancy wastage & birth anomalies; ovarian cancer. Increased chance of multiple & ectopic pregnancy. Exercise caution in patients w/ uterine fibroids. May affect ability to drive & use machines. Not indicated during pregnancy. Lactation.
Adverse Reactions
Ovarian enlargement, vasomotor flushes, abdominal-pelvic discomfort (distension, bloating), nausea & vomiting, breast discomfort, visual symptoms, headache, intermenstrual spotting or menorrhagia.
MIMS Class
Trophic Hormones & Related Synthetic Drugs
ATC Classification
G03GB02 - clomifene ; Belongs to the class of synthetic agents used as ovulation stimulants.
Duinum tab 50 mg
1 × 10's
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