Exclude malignancy in the presence of significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or malaena & when gastric ulcer is suspected or present. Monitor liver enzymes regularly in patients w/ severe liver impairment particularly on long-term use. Increased risk of Clostridium difficile
-associated diarrheoa & osteoporosis-related fractures of the hip, wrist or spine. Monitor Mg levels prior to initiation of PPI treatment & periodically. Symptomatic & asymptomatic hypomagnesaemia. Concomitant w/ methotrexate. Co-administration w/ HIV PIs is not recommended. May reduce vit B12
absorption. May affect ability to drive or operate machinery. Do not use during pregnancy. Lactation.