Concise Prescribing Info
Eradication of H. pylori in patients w/ peptic ulcer. Duodenal & gastric ulcer. Moderate & severe reflux oesophagitis.
Dosage/Direction for Use
Eradication of H. pylori 40 mg bd w/ amoxicillin 1,000 mg bd & clarithromycin 500 mg bd OR 40 mg bd w/ metronidazole 500 mg bd & clarithromycin 500 mg bd OR 40 mg bd w/ amoxicillin 1,000 mg bd & metronidazole 500 mg bd. Duodenal & gastric ulcer & reflux esophagitis 1 tab daily, may be increased to 2 tab daily. Severe liver impairment Max: 20 mg daily.
Should be taken on an empty stomach: Take 1 hr before meals. Swallow whole, do not chew/crush.
Hypersensitivity. Combination treatment for eradication of H. pylori in patients w/ moderate to severe liver or kidney function disturbances.
Special Precautions
Exclude malignancy in the presence of significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or malaena & when gastric ulcer is suspected or present. Monitor liver enzymes regularly in patients w/ severe liver impairment particularly on long-term use. Increased risk of Clostridium difficile-associated diarrheoa & osteoporosis-related fractures of the hip, wrist or spine. Monitor Mg levels prior to initiation of PPI treatment & periodically. Symptomatic & asymptomatic hypomagnesaemia. Concomitant w/ methotrexate. Co-administration w/ HIV PIs is not recommended. May reduce vit B12 absorption. May affect ability to drive or operate machinery. Do not use during pregnancy. Lactation.
Adverse Reactions
Drug Interactions
May reduce or increase absorption of pH-dependent drugs (eg, ketoconazole). Reduced bioavailability of HIV PIs eg, atazanavir, nelfinavir. Coumarin anticoagulants eg, phenprocoumon or warfarin (monitor prothrombin time/INR). May elevate & prolong serum levels of methotrexate &/or its metabolite hydroxymethotrexate. Increased systemic exposure w/ CYP2C19 inhibitors (eg, tacrolimus & fluvoxamine).
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Duonazole EC tab 40 mg
2 × 7's
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