Duromine Capsule

Duromine Capsule





Zuellig Pharma
Concise Prescribing Info
Phentermine as an ion-exchange resin complex
As short-term adjunct in the management of obesity in a medically monitored comprehensive regimen of wt reduction based on exercise, diet & behaviour modification in obese patients w/ body mass index (BMI) of ≥30 kg/m2. Can be initiated in overwt patients w/ BMI of 25-29.9 kg/m2 which increases morbidity risk from a number of disorders.
Dosage/Direction for Use
Adult & childn >12 yr 1 cap daily. Recommended starting dose: 30 mg daily. Recommended continuous or intermittent maintenance dose: 15-30 mg daily depending on responsiveness.
Should be taken with food: Take at breakfast. Avoid taking near bedtime. Swallow whole, do not chew/crush.
Pulmonary artery HTN; existing heart valve abnormalities or heart murmurs; moderate to severe arterial HTN; cerebrovascular disease; severe cardiac disease including arrhythmias, advanced arteriosclerosis; hypersensitivity to sympathomimetics; hyperthyroidism; agitated states or a history of psychiatric illness including anorexia nervosa & depression; glaucoma; history of drug/alcohol abuse or dependence; concomitant treatment w/ MAOIs or w/in 14 days following MAOI administration. Pregnancy, lactation.
Special Precautions
Exclude secondary organic causes of obesity by diagnosis prior to therapy. Not recommended to be co-administered w/ drug products for wt loss. Valvular heart disease, primary pulmonary HTN, mild HTN, diabetes, established CAD, epilepsy, patients receiving psychotrophic drugs or antihypertensives. May impair the ability to drive or operate machinery. Wt loss should be gradual & controlled.
Adverse Reactions
Dry mouth, GI upsets, palpitations, tachycardia, elevated BP, overstimulation, restlessness, insomnia, tremor, headache, micturition disturbances, rash.
Drug Interactions
Sympathomimetics. Antagonises adrenergic neurone blockers. Effects potentiated by MAOIs (stop for at least 14 days prior). Concurrent use w/ thyroid hormones may increase CNS stimulation. Alcohol may potentiate CNS side effects.
MIMS Class
ATC Classification
A08AA01 - phentermine ; Belongs to the class of centrally acting antiobesity products. Used in the treatment of obesity.
Duromine Capsule SR cap 15 mg
Duromine Capsule SR cap 30 mg
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