Econazole


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Nail fungal infections
Adult: As 1% cream or lotion: Apply once daily under occlusive dressing. For tinea pedis: As 1% cream or foam: Apply once daily for 4 wk.
Child: ≥12 yr For tinea pedis: As 1% foam: Apply once daily for 4 wk.

Topical/Cutaneous
Tinea corporis, Tinea cruris, Tinea versicolor
Adult: As 1% cream: Apply once daily for 2 wk.

Topical/Cutaneous
Cutaneous candidiasis
Adult: As 1% cream: Apply bid (morning and evening) for 2 wk.

Vaginal
Vaginal candidiasis
Adult: As pessary: Insert 150 mg pessary intravaginally at bedtime for 3 consecutive nights, or as single dose in long-acting preparations.
Contraindications
Hypersensitivity.
Special Precautions
Patient using spermicidal contraceptives. Pregnancy and lactation.
Adverse Reactions
Burning and stinging sensation, pruritus, erythema, rash; contact dermatitis.
Patient Counseling Information
May damage latex contraceptive diaphragms and condoms, avoid use during treatment. Avoid contact w/ eyes, nose, mouth or other mucous membranes. Avoid heat, flame and smoking upon application of foam preparation.
Drug Interactions
May enhance anticoagulant effect of warfarin or acenocoumarol.
Action
Description: Econazole modifies the permeability of cell wall membrane in fungi; may interfere w/ RNA and protein synthesis, and lipid metabolism.
Pharmacokinetics:
Absorption: Insignificant (topical or vaginal).
Chemical Structure

Chemical Structure Image
Econazole

Source: National Center for Biotechnology Information. PubChem Database. Econazole, CID=3198, https://pubchem.ncbi.nlm.nih.gov/compound/Econazole (accessed on Jan. 21, 2020)

Storage
Store between 15-30°C.
References
Anon. Econazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/07/2014.

Buckingham R (ed). Econazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

Econazole Nitrate Cream (Prasco Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

Ecoza Aerosol, Foam (Quinnova Pharmaceuticals, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Econazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/07/2014.

Disclaimer: This information is independently developed by MIMS based on Econazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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