levothyroxine sodium


Aspen Pharmacare


DCH Auriga
Concise Prescribing Info
Thyroxine Na
Dosage/Direction for Use
Adult Initially 50-100 mcg daily, adjusted at 3-4 wk intervals by 50 mcg until normal metabolism is steadily maintained. Usual dose: 100-200 mcg daily. Patient >50 yr Initially max 50 mcg daily. Cardiac disease 25 mcg daily or 50 mcg on alternate days, may be increased by 25 mcg at intervals of 4 wk. Congenital hypothyroidism Infant Initially 25 mcg daily w/ increments of 25 mcg every 2-4 wk until optimum response is achieved. Juvenile myxoedema Childn >1 yr Initially 2.5-5 mcg/kg daily.
Should be taken on an empty stomach: Take preferably before breakfast. Do not crush/divide.
Hypersensitivity. Thyrotoxicosis. Patients w/ untreated subclinical (suppressed serum TSH level w/ normal T3 & T4 levels) or overt thyrotoxicosis of any aetiology. Acute MI, myocarditis & pancarditis; untreated adrenal & pituitary insufficiency.
Special Precautions
Not to be used for treatment of obesity or wt loss. Patients w/ cardiac symptoms, DM or insipidus; panhypopituitarism or other causes predisposing to adrenal insufficiency; myxoedema, malabsorption syndromes. Monitor thyroid function test. Long-term therapy. Pregnancy & lactation.
Drug Interactions
Decreased absorption w/ cholestyramine, Ca, Al, Mg, Fe supplements, polystyrene sulfonates, sucralfate, lanthanum, bile acid sequestrants (eg, colestipol), anion/cation exchange resins (eg, kayexalate, sevelamer), proton pump inhibitors & orlistat (if possible, separate doses for 4 hr). Soy-containing compd & high-fiber diet. Dose requirements may be altered due to increased thyroid hormone metabolism & displacement from plasma proteins by anticonvulsants (eg, carbamazepine, phenytoin). Increased metabolism & excretion by enzyme inducers (eg, rifampicin & barbiturates). Partial inhibition of peripheral T4 to T3 transformation by propranolol, amiodarone, lithium, iodide, oral contrast agents, propylthiouracil, glucocorticoids. Increased dosage requirements by tyrosine kinase inhibitors (eg, imatinib, sunitinib). Reduced serum levels by sertraline. May increase serum conc of levothyroxine-binding globulin w/ OCs, oestrogen, tamoxifen, clofibrate, methadone, 5-FU. May increase thyroid hormone requirements w/ HMG-CoA reductase inhibitors eg, simvastatin & lovastatin.
MIMS Class
ATC Classification
H03AA01 - levothyroxine sodium ; Belongs to the class of thyroid hormones.
Eltroxin tab 100 mcg
Eltroxin tab 50 mcg
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