Endoxan

Endoxan

cyclophosphamide

Manufacturer:

Baxter Oncology

Distributor:

Transmedic
Concise Prescribing Info
Contents
Cyclophosphamide
Indications/Uses
Chemotherapy of malignant tumours & leukaemia.
Dosage/Direction for Use
Initial treatment: Generally by IV inj, daily 3-6 mg/kg body wt (120-240 mg/m2) or massive-intermittent therapy: 10-15 mg/kg body wt (400-600 mg/m2) w/ therapy-free intervals of 2 or 5 days or 20-40 mg/kg body wt (800-1600 mg/m2), w/ therapy-free intervals of 10-20 days. Maintenance: 50-200 mg/day orally.
Administration
Should be taken on an empty stomach: May be taken w/ meals to minimise GI irritation. Ensure adequate fluid intake. Swallow whole.
Contraindications
Acute infection, severe bone marrow depression, acute UTI. Severe hepatic impairment. Pregnancy.
Special Precautions
Patients of reproductive age should use contraceptives throughout therapy & for not <6 mth afterwards. DM; elderly & debilitated patients; renal & hepatic failure.
Adverse Reactions
GI upsets; alopecia; reticulo-endothelial system depression; hematuria; reversible amenorrhea & azoospermia; myocardial damage w/ very high doses; pigmentation, macrocytosis, water retention; induction of hyperglycemia or hypoglycemia; risk of secondary malignancies.
Drug Interactions
May potentiate hypoglycemic effect of sulfonylureas. Allopurinol (increased incidence of bone marrow depression). Suxamethonium (prolongation of apnoea).
ATC Classification
L01AA01 - cyclophosphamide ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Endoxan powd for inj 1000 mg
Packing/Price
(vial) 1's ($33.5/box)
Form
Endoxan coated tab 50 mg
Packing/Price
1000's;50's
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