Leukaemias, acute or chronic lymphatic and myeloid leukaemia. Malignant lymphomas. Paraproteinaemias eg, plasmacytoma. Waldenstroem's disease. Malignant solid tumours especially carcinoma of the ovaries or breast, small-cell bronchial carcinoma, neuroblastoma, seminoma, Ewing's sarcoma. Postoperative adjuvant treatment of chemosensitive tumours.
"Autoimmune diseases" including rheumatoid arthritis (progressive chronic polyarthritis, arthropathia psoriatica), lupus erythematosus, scleroderma, systemic vasculitides (eg, with nephrotic syndrome), certain types of glomerulonephritis (eg, with nephrotic syndrome), myasthenia gravis, autoimmune haemolytic anaemia, cold agglutination diseases. Organ and bone marrow transplantations. Endoxan should be used in nonmalignant conditions only in case of a vital indication and only if conventional treatment has failed.