Endoxan

Endoxan Mechanism of Action

cyclophosphamide

Manufacturer:

Baxter Oncology

Distributor:

Transmedic
Full Prescribing Info
Action
A cytostatic drug from the group of alkylating agents.
Pharmacology: Cyclophosphamide is inactive under in vitro conditions and is converted into its active form in the body. The cytostatic action of cyclophosphamide and its metabolites is due to intervention in the G2- and S-phase. Whether alkylation of the DNA is the only cause of the cytostatic effect or whether this can be explained in some other way (inhibition of the chromatin transformation processes, inhibition of DNA-polymerases) still needs to be elucidated.
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