Hypotension, palpitation, tachycardia and alterations in electrocardiogram patterns may rarely occur.
If drowsiness, dizziness, sleep disorder, headache, tremor or infrequently anaphrodisia, excitement, hypomnesis, oculogyric crisis, paresthesia, dysarthria and ataxia occur, dosage should be reduced or Espin should be discontinued.
If hypersensitivity symptom eg, eruption occurs, Espin should be discontinued.
If hemopathy eg, leukopenia occurs, Espin should be discontinued.
The elevation of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase may occur.
Dipsia, constipation, anorexia, infrequently nausea, vomiting, diarrhea and abdominal pain may occur.
Syndrome of inappropriate antidiuretic hormone (SIADH) eg, hyponatremia, hypotonic symptom, isosthenuria convulsion and clouding of consciousness has been reported in patients receiving similar compound (amitrypsin).
Other Adverse Reaction:
Weariness, urinary retention and rhinocleisis may occur.