Adult: Initially, 500 mg daily in 2 divided doses, may increase in increments of 250 mg at 4-7 days interval. Usual dose: 1-1.5 g daily in 2 divided doses. Max: up to 2 g daily. Child: <6 yr Initially, 250 mg daily, may increase gradually in small increments every few days to a usual dose of 20 mg/kg daily. Max: 1 g daily; ≥6 yr Same as adult dose.
May be taken with or without food.
Hypersensitivity w/ ethosuximide.
Hepatic or renal impairment. Pregnancy and lactation.
Description: Ethosuximide, a succinimide derivative, suppresses paroxysmal spike-and-wave pattern common to absence seizure. It depresses nerve transmission in the motor cortex and increases seizure threshold, hence reducing the frequency of epileptiform attack. Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Time to peak serum concentration: 1-7 hr. Distribution: Widely distributed throughout the body. Crosses placenta and enters breast milk. Volume of distribution: 0.7 L/kg. Metabolism: Extensively hydroxylated in the liver to 3 inactive metabolites. Excretion: Via urine (mainly as metabolites; 12-20% as unchanged drug). Elimination half-life: 50-60 hr.
N03AD01 - ethosuximide ; Belongs to the class of succinimide derivatives antiepileptics.
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