Euthyrox

Levothyroxine Na

Benign euthyroid goitre & prophylaxis of relapse after surgery. Substitution therapy in hypothyroidism. Concomitant therapy during anti-thyroid medicinal treatment of hyperthyroidism. Suppression therapy in thyroid cancer. 100 mg-tab Diagnostic use for thyroid suppression testing.

Benign euthyroid goiter & prophylaxis of relapse after surgery for euthyroid goiter 75-200 mcg once daily. Hypothyroidism Adult Initially 25-50 mcg once daily. Maintenance: 100-200 mcg once daily. Childn Initially 12.5-50 mcg once daily. Maintenance: 100-150 mcg/m² BSA. Thyroid cancer 150-300 mcg once daily. Concomitant hyperthyroidism supplementation 50-100 mcg once daily. Thyroid suppression testing 200 mcg once daily for wk 1 & 2 prior to test.

Should be taken on an empty stomach: Take 30 min to 1 hr before meals.

Hypersensitivity. Untreated adrenal & pituitary insufficiency; hyperthyroidism or untreated thyrotoxicosis; acute MI, myocarditis & pancarditis. Pregnancy.

Coronary, pituitary & adrenal insufficiency, angina pectoris, arteriosclerosis, HTN & thyroid autonomy, heart failure, tachycardiac arrhythmias. Hypothyroidism. Close monitoring of thyroid function. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Lactation.

Tachycardia, palpitation, cardiac arrhythmias, angina pectoris, headache, muscular weakness & cramps, flushing, fever, vomiting, menstruation disorders, pseudotumour cerebri, tremor, restlessness, insomnia, hyperhidrosis, wt loss, diarrhoea.

May influence the effect w/ protease inhibitor (eg, ritonavir, indinavir, lopinavir); phenytoin. May reduce the effect of antidiabetics. Increase risk of haemorrhage of coumarin derivatives. Intensified effect w/ salicylates, dicumarol, furosemide, clofibrate. May decrease absorption w/ sevelamer. May decrease efficacy w/ tyrosine kinase inhibitor (eg, imatinib, sunitinib). May inhibit the absorption w/ ion exchange resins (eg, cholestyramine or cholestipol). Decreased effect w/ Al- & Fe-containing products, Ca carbonate. May inhibit the peripheral conversion of T₄-T₃ w/ propylthiouracil, glucocorticoids, β-sympatholytics, amiodarone. Iodine-containing contrast media can trigger hyperthyroidism. Decreased efficacy & increased the serum TSH level w/ sertraline, chloroquine/proguanil. Increased hepatic clearance w/ hepatic enzyme induction (eg, barbiturates, carbamazepine). Oestrogens. Decreased intestinal absorption w/ soy-containing compd.

Thyroid Hormones

H03AA01 - levothyroxine sodium ; Belongs to the class of thyroid hormones.

POM