May influence the effect w/ protease inhibitor (eg, ritonavir, indinavir, lopinavir); phenytoin. May reduce the effect of antidiabetics. Increase risk of haemorrhage of coumarin derivatives. Intensified effect w/ salicylates, dicumarol, furosemide, clofibrate. May decrease absorption w/ sevelamer. May decrease efficacy w/ tyrosine kinase inhibitor (eg, imatinib, sunitinib). May inhibit the absorption w/ ion exchange resins (eg, cholestyramine or cholestipol). Decreased effect w/ Al- & Fe-containing products, Ca carbonate. May inhibit the peripheral conversion of T4
w/ propylthiouracil, glucocorticoids, β-sympatholytics, amiodarone. Iodine-containing contrast media can trigger hyperthyroidism. Decreased efficacy & increased the serum TSH level w/ sertraline, chloroquine/proguanil. Increased hepatic clearance w/ hepatic enzyme induction (eg, barbiturates, carbamazepine). Oestrogens. Decreased intestinal absorption w/ soy-containing compd.