Treatment and prophylaxis of haemorrhagic episodes in patients with haemophilia A
Adult: Dosage is individualised based on coagulation tests performed before treatment and at regular intervals during treatment. Generally, 1 IU/kg will increase circulating factor VIII levels by about 2 IU/dL. Recommended doses vary according to the preparation used. Suggested doses: Mild-moderate haemorrhage (increase to 20-30% of normal): Usually with a single dose of 10-15 units/kg; more serious haemorrhage or minor surgery (increase to 30-50% of normal): Usual initial dose of 15-25 units/kg followed by 10-15 units/kg every 8-12 hr if required; severe haemorrhage or major surgery (increase to 80-100% of normal): Usual initial dose of 40-50 units/kg followed by 20-25 units/kg every 8-12 hr. Refer to individual product information for further dosing details.
Prophylaxis in severe haemophilia A
Adult: 10-50 u/kg every 2-3 days, as needed.