Furazolidone


Generic Medicine Info
Indications and Dosage
Oral
Cholera, Giardiasis
Adult: 100 mg 4 times daily. Usual duration: 2-5 days, up to 7 days in some patients or 10 days for giardiasis.
Child: 1.25 mg/kg 4 times daily, usually given for 2-5 days or up to 10 days for giardiasis.
Administration
Should be taken with food. Avoid food & beverage containing tyramine or tryptophan, eg, alcohol, beer (including alcohol-free beer), cheese, yoghurt.
Contraindications
Hypersensitivity, infants <1 mth. Alcohol.
Special Precautions
Pregnancy, lactation, G6PD deficiency.
Adverse Reactions
Hypersensitivity, hypoglycaemia, orthostatic hypotension, dizziness, drowsiness, headache, malaise, nausea, vomiting, rash, fever, arthralgia, brown urine, haemolytic anaemia.
Potentially Fatal: Agranulocytosis. Hypertensive crisis with MAOIs.
Drug Interactions
Disulfiram-like reaction with alcohol. Potential hypertensive crisis with sympathomimetics, tyramine-containing foods, levodopa.
Potentially Fatal: Potentiation of MAOIs. Toxic psychosis with amitriptyline.
Food Interaction
Reaction with foods rich in tyramine.
Action
Description: Furazolidone has a broad antibacterial spectrum which is active against susceptible organisms including E. coli, staphylococci, Giardia sp. and against salmonella, shigella, proteus, and V. cholerae. Its bactericidal action is by interfering with bacterial enzyme systems.
Pharmacokinetics:
Absorption: Poor (oral).
Excretion: Urine (as active drug and metabolites).
Disclaimer: This information is independently developed by MIMS based on Furazolidone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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