tranexamic acid




Concise Prescribing Info
Tranexamic acid
Local fibrinolysis eg, epistaxis, prostatectomy, cervical conization & dental extraction in patients w/ coagulopaties. Hereditary angioneurotic edema. General fibrinolysis after major surgery.
Dosage/Direction for Use
IV Recommended standard dose: 5-10 mL by slow IV inj at a rate of 1 mL/min. General fibrinolysis 2 amp of 5 mL by slow IV inj every 6-8 hr. Prostatectomy 1-2 amp of 5 mL by slow IV inj every 6-8 hr (1st inj given during operation) for the 1st 3 days after surgery. Dental extraction (in patients w/ coagulopathies) 10 mg/kg IV immediately before surgery. Moderate to severe renal impairment: >500 micromol/L 5 mg/kg daily, 250-500 micromol/L 10 mg/kg daily, 120-249 micromol/L 10 mg/kg bd. Topical Epistaxis Soak a gauze strip in the soln then packing the nasal cavity.
Hypersensitivity. Active thromboembolic disease eg, DVT, pulmonary embolism & cerebral thrombosis. Subarachnoid haemorrhage.
Special Precautions
Irregular menstrual bleeding. Patients w/ high risk for thrombosis (previous thromboembolic event & family history of thromboembolic disease); disseminated intravascular coagulation. Renal insufficiency. Ureteric obstruction. Convulsions. Pregnancy & lactation. Menorrhagic childn <15 yr.
Adverse Reactions
Nausea, vomiting, diarrhoea.
Drug Interactions
Not to be added to blood transfusion or inj containing penicillin.
MIMS Class
ATC Classification
B02AA02 - tranexamic acid ; Belongs to the class of amino acid antifibrinolytics. Used in the treatment of hemorrhage.
Haemostop 100 mg per 1 mL soln for inj
5 mL x 1's
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