Herbesser

Herbesser

diltiazem

Manufacturer:

Mitsubishi Tanabe Pharma

Distributor:

Pharmaforte
Concise Prescribing Info
Contents
Diltiazem HCl
Indications/Uses
Angina pectoris, variant angina pectoris. Mild to moderate essential HTN.
Dosage/Direction for Use
Adult Angina pectoris, variant angina pectoris 30 mg tds, may be increased to 60 mg tds if necessary. Mild to moderate essential HTN 30-60 mg tds.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity. Severe CHF; 2nd- or 3rd-degree. AV block of sick sinus syndrome. Pregnancy.
Special Precautions
CHF; severe bradycardia (<50 beats/min) or 1st degree AV block; severe hypotension; severe renal & hepatic dysfunction. Concomitant use of other antiarrhythmic agents (eg, disopyramide phosphate w/ terfenadine). May affect ability to drive or operate machinery. Lactation. Childn. Elderly.
Adverse Reactions
Stomach discomfort, constipation, abdominal pain; dizziness, bradycardia, facial hot flushes, AV block, hypersensitivity, headache.
Drug Interactions
Enhanced hypotensive effect by antihypertensive agents & nitrates (eg, isosorbide nitrates, nitroglycerin). Enhanced effects of dihydropyridine Ca antagonists (eg, nifedipine). Bradycardia, AV & SA block may occur w/ β-blocking agents (eg, bisoprolol fumarate, propranolol HCl, atenolol) & rauwolfia prep (eg, reserpine). Increased symptoms of toxicity of digitalis prep (eg, digoxin, metildigoxin). Bradycardia, AV block, sinus arrest may occur w/ antiarrhythmic drugs (eg, amiodarone HCl, mexilentine HCl) & anesth (eg, isoflurane, enflurane, halothane). Increased blood conc of aprindin HCl, cyclosporin, tacrolimus, carbamazepine, phenytoin. Enhanced the effect of theophylline, triazolam, midazolam & muscle relaxants (eg, pancuronium Br, vecuronium Br). Increased blood conc w/ cimetidine, HIV PIs (eg, ritonavir, saquinavir mesylate). Decreased effect w/ rifampicin.
ATC Classification
C08DB01 - diltiazem ; Belongs to the class of benzothiazepine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Herbesser tab 60 mg
Packing/Price
10 × 10's
Form
Herbesser tab 30 mg
Packing/Price
10 × 10's
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