In case of fractionated application (short infusion), a total dose of 250-300 mg/kg/course should be aimed at. Usual schedule: 50-60 mg/kg IV daily for 5 consecutive days. Therapy-resistant cases: 80 mg/kg daily for 2-3 consecutive days. Also see lit.
GI upsets; alopecia; reduction in blood count; cystitis; reversible encephalopathy. Immunosuppression. Occasionally, renal, hepatic & cardiac dysfunction in rare cases. Risk of secondary malignancies.
Neurotoxicity, hematotoxicity & nephrotoxicity may be increased by prior cisplatin therapy. Increased hypoglycemic effects w/ sulfonylureas. Increased bone marrow depression w/ allopurinol. Disturbances of anticoagulant control of warfarin.