Hyzaar/Hyzaar Plus/Hyzaar Forte

Hyzaar/Hyzaar Plus/Hyzaar Forte Dosage/Direction for Use

losartan + hydrochlorothiazide




Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
HYZAAR may be administered with other antihypertensive agents.
HYZAAR may be administered with or without food.
Hypertension: The usual starting and maintenance dose is one tablet of HYZAAR (losartan potassium 50 mg/hydrochlorothiazide 12.5 mg) once daily. For patients who do not respond adequately to HYZAAR, the dosage may be increased to one tablet of HYZAAR FORTE (losartan potassium 100 mg/hydrochlorothiazide 25 mg) once daily or two tablets of HYZAAR once daily. The maximum dose is one tablet of HYZAAR FORTE or two tablets of HYZAAR once daily. In general, the antihypertensive effect is attained within three weeks after initiation of therapy. HYZAAR PLUS (losartan potassium 100 mg/hydrochlorothiazide 12.5 mg) is available for those patients titrated to 100 mg of COZAAR who require additional blood pressure control.
HYZAAR/HYZAAR PLUS/HYZAAR FORTE should not be initiated in patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics).
HYZAAR/HYZAAR PLUS/HYZAAR FORTE is not recommended for patients with severe renal impairment (creatinine clearance ≤30 mL/min) or for patients with hepatic impairment.
No initial dosage adjustment for HYZAAR is necessary for elderly patients. HYZAAR FORTE/HYZAAR PLUS should not be used as the initial dose in elderly patients.
Reduction in the Risk of Stroke in Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is 50 mg of losartan once daily. If goal blood pressure is not reached with losartan 50 mg, therapy should be titrated using a combination of losartan and a low dose of hydrochlorothiazide (12.5 mg) and, if needed, the dose should then be increased to losartan 100 mg and hydrochlorothiazide 12.5 mg once daily. If necessary, the dose should be increased to losartan 100 mg and hydrochlorothiazide 25 mg once daily. HYZAAR, HYZAAR PLUS and HYZAAR FORTE are suitable alternative formulations in patients who would otherwise be treated concomitantly with losartan plus hydrochlorothiazide.
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