Indigo carmine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Singapore prescribing information.

Generic Medicine Info

Indications and Dosage

Parenteral
Marker dye in urological procedures

Adult: 40 mg preferably via slow IV inj. May also be given via IM inj.

Contraindications

Uncontrolled heart failure, history of allergic reactions, haemodynamic instability.

Special Precautions

Patient with heart rate and conduction disorders, hypertension, coronary disorders. Pregnancy and lactation.

Adverse Reactions

Significant: Idiosyncratic reactions (e.g. rash, pruritus bronchoconstriction), paradoxical pressor effects.
Cardiac disorders: Bradycardia.
Gastrointestinal disorders: Nausea, vomiting.
Skin and subcutaneous tissue disorders: Skin discoloration (large doses in children and underweight patients).
Vascular disorders: Hypertension.

Pregnancy Category (US FDA)

IM/IV/Parenteral: C

Overdosage

Symptoms: Hypertensive crisis and severe bradycardia. Management: May administer peripheral vasodilators.

Lab Interference

May interfere with colorimetric methods of urinalysis.

Action

Description: Indigo carmine is a marker dye which retains its blue colour during passage through the body. It is used in the test of renal function.arker
Pharmacokinetics:
Excretion: Via urine. Elimination half-life: 4-5 minutes (IV).

Chemical Structure

Storage

Store between 15-30°C. Protect from light.

MIMS Class

Radiographic & Diagnostic Agents

ATC Classification

V04CH02 - indigo carmine ; Belongs to the class of diagnostic agents used to test for renal function.

References

Anon. Indigotindisulfonate Sodium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/07/2020.

Anon. Indigotinedisulfonate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 16/07/2020.

Buckingham R (ed). Indigo Carmine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/07/2020.

Indigo Carmine 40 mg/5 mL Solution for Injection (SERB S.A.). MHRA. https://products.mhra.gov.uk/. Accessed 16/07/2020.

Indigo Carmine Injection, Solution (American Regent, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/07/2020.

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