Ipolipid

Ipolipid

gemfibrozil

Manufacturer:

Medochemie

Distributor:

Medochemie
Full Prescribing Info
Contents
Gemfibrozil.
Description
Gemfibrozil is 5-(2.5-dimethylphenoxy)-2,2-dimethylpentanoic acid.
Ipolipid is a valeric acid derivative.
Action
Ipolipid is a lipid-regulating agent which lowers elevated serum lipids primarily by decreasing serum triglyceride with a variable reduction in total serum cholesterol.
These decreases occur primarily in the very low-density lipoprotein (VLDL) fractions and less frequently in the low-density lipoprotein (LDL) fraction. In addition, Ipolipid increases the high-density lipoprotein (HDL). The mechanism of action is not clear.
Ipolipid is well absorbed by oral route. Peak plasma levels occur in 1-2 hrs after oral administration with a plasma t½ of 1.5 hrs following single dose.
Indications/Uses
Lipid disorders eg, Fredrickson types IIA, IIB, III, IV and V; hyperlipidemia associated with diabetes; and xanthomata associated with hyperlipidemias.
Prevention of coronary heart disease.
Dosage/Direction for Use
Adults: Recommended Dose: 1200 mg daily in 2 divided doses 30 min before morning and evening meal. Some patients will experience therapeutic effect on 900 mg/day, a few may require 1500 mg/day for satisfactory results.
Overdosage
While there has been no reported case of overdosage, symptomatic supportive measures should be taken should it occur.
Contraindications
Hepatic renal dysfunction.
Special Precautions
Gemfibrozil should be used with caution in patients receiving anticoagulants. The dosage of anticoagulants should be reduced by ½ to maintain prothrombin time at the desired level to prevent bleeding complications. Frequent prothrombin determinations are advisable until the prothrombin level is stabilized.
Use in pregnancy: Safety in pregnancy has not been established.
Use In Pregnancy & Lactation
Use in pregnancy: Safety in pregnancy has not been established.
Adverse Reactions
Gastrointestinal complaints were the most frequent reported adverse reactions but were not usually severe enough to necessitate cessation of therapy.
Drug Interactions
Concurrent use of gemfibrozil with anticoagulants coumarin-orindandione derivative, may significantly increase the anticoagulant effect; adjustment of anticoagulant dosage based on frequent prothrombin time determinations is recommended.
Storage
Store in a dry place at a temperature not exceeding 25°C. Protect from light.
ATC Classification
C10AB04 - gemfibrozil ; Belongs to the class of fibrates. Used in the treatment of hyperlipidemia.
Presentation/Packing
Cap 300 mg x 5 x 10's. Tab 600 mg x 10 x 10's.
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