Discontinue use if severe skin or hypersensitivity reactions develop. Risk for severe, potentially life-threatening, & fatal skin reactions (including Stevens-Johnson syndrome & toxic epidermal necrolysis) when concomitantly used w/ other drugs. Not recommended to be coadministered w/ Al- & Mg-containing antacids; atazanavir; tipranavir/ritonavir; strong inducers of UGT1A1 (eg, rifampin). Risk of immune reconstitution syndrome; autoimmune disorders (eg, Graves' disease) may also occur in the immune reconstitution setting. Risk of osteonecrosis particularly in patients w/ advanced HIV disease &/or long-term exposure to combination anti-retroviral therapy. Not to be taken by patients w/ rare hereditary problems of galactose intolerance. Severe hepatic impairment; monitor patients w/ preexisting liver dysfunction including chronic hepatitis; increased risk for severe & potentially fatal hepatic adverse events in patients w/ chronic hepatitis B or C. Pregnancy. Breastfeeding is not recommended during therapy. Infant <4wk. Elderly ≥65 yr.