Isosorbide dinitrate is used to prevent and treat angina (chest pain which occurs when the heart does not receive enough blood and oxygen).
This medicine may also be used to manage heart failure and to treat diffuse oesophagal spasm (painful muscle contraction affecting the oesophagus).
Isosorbide Dinitrate may be used to treat other conditions as decided by your doctor.
Take Isosorbide dinitrate exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Take it on an empty stomach, at least half an hour before meals.
Try to take it at the same time each day.
If you are taking the extended-release type of tablet (usually labelled as “ER”), swallow it whole with a glass of water. Do not divide, chew or crush the tablet.
This medicine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- heart disease
- increased pressure around the brain caused by brain injury or tumour
- anaemia (low red blood cell count)
- very low blood pressure
as Isosorbide dinitrate may not be suitable for you.
Do not take Isosorbide dinitrate with medicines used to treat impotence and medicines used to manage high blood pressure in the arteries of the lungs. Please see the section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have the following conditions:
- liver disease
- kidney disease
- glaucoma (increased pressure inside the eye)
- thyroid disease
- hypothermia (low body temperature)
Let your doctor know if you are pregnant or breastfeeding.
If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
You may feel dizzy when getting up from a sitting or lying down position, especially if you are taking Isosorbide dinitrate for the very first time. This is common and should improve gradually as you get used to Isosorbide dinitrate. It will help if you get up slowly from a sitting or lying down position. If you are taking this medicine for the very first time, take the first dose of Isosorbide dinitrate at bedtime to minimise dizziness.
Isosorbide dinitrate may also cause headache, and lightheadedness.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
DO NOT take Isosorbide dinitrate with medicines used to treat impotence (e.g. sildenafil, tadalafil, vardenafil), and medicines used to manage high blood pressure in the arteries of the lungs (e.g. riociguat).
Inform your doctor and pharmacist if you are taking any of medicines:
- medicines for high blood pressure e.g. atenolol, nifedipine, doxazosin
- dihydroergotamine (medicine for migraine)
- medicines for arrhythmia (irregular heartbeat) e.g. disopyramide
- medicines for depression e.g. nefazodone, duloxetine
- medicines for mood disorders e.g. risperidone
This list does not include all medicines that may interact with Isosorbide dinitrate.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.