Isosorbide dinitrate - oral

Patient Medicine Information
Why do I need this medicine?
Isosorbide dinitrate is used to prevent and treat angina (chest pain which occurs when the heart does not receive enough blood and oxygen).

This medicine may also be used to manage heart failure and to treat diffuse oesophagal spasm (painful muscle contraction affecting the oesophagus).

Isosorbide Dinitrate may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Isosorbide dinitrate exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take it on an empty stomach, at least half an hour before meals.

Try to take it at the same time each day.

If you are taking the extended-release type of tablet (usually labelled as “ER”), swallow it whole with a glass of water. Do not divide, chew or crush the tablet.

This medicine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • heart disease
  • increased pressure around the brain caused by brain injury or tumour
  • anaemia (low red blood cell count)
  • very low blood pressure
as Isosorbide dinitrate may not be suitable for you.

Do not take Isosorbide dinitrate with medicines used to treat impotence and medicines used to manage high blood pressure in the arteries of the lungs. Please see the section “Can I take this with other medicines?” below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • liver disease
  • kidney disease
  • glaucoma (increased pressure inside the eye)
  • thyroid disease
  • hypothermia (low body temperature)
  • malnutrition
Let your doctor know if you are pregnant or breastfeeding.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
What side effects could I experience?
You may feel dizzy when getting up from a sitting or lying down position, especially if you are taking Isosorbide dinitrate for the very first time. This is common and should improve gradually as you get used to Isosorbide dinitrate. It will help if you get up slowly from a sitting or lying down position. If you are taking this medicine for the very first time, take the first dose of Isosorbide dinitrate at bedtime to minimise dizziness.

Isosorbide dinitrate may also cause headache, and lightheadedness.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
DO NOT take Isosorbide dinitrate with medicines used to treat impotence (e.g. sildenafil, tadalafil, vardenafil), and medicines used to manage high blood pressure in the arteries of the lungs (e.g. riociguat).

Inform your doctor and pharmacist if you are taking any of medicines:
  • medicines for high blood pressure e.g. atenolol, nifedipine, doxazosin
  • dihydroergotamine (medicine for migraine)
  • medicines for arrhythmia (irregular heartbeat) e.g. disopyramide
  • medicines for depression e.g. nefazodone, duloxetine
  • medicines for mood disorders e.g. risperidone
This list does not include all medicines that may interact with Isosorbide dinitrate.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on isosorbide dinitrate - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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