Ivacaftor - oral

Patient Medicine Information
Why do I need this medicine?
Ivacaftor is used to treat cystic fibrosis (an inherited condition that causes excessively thick and sticky mucus that can clog the lungs causing difficulty of breathing, and it can also block the pancreas which can affect the digestion of food).
How do I take this medicine?
Take Ivacaftor exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine with fat-containing meals (e.g. cheese, avocados, soy-based products, nuts, meat, oily fish). Try to take it at the same time each day.

Ivacaftor is available as oral granules for suspension and film-coated tablets.

If you are taking granules, swallow the granules with a full glass of water or mix it with a spoonful of soft foods such as applesauce, carrots, rice or ice cream, or other liquid such as baby formula or breast milk and drink immediately.

If you are taking a film-coated tablet, swallow it whole. Do not divide, chew or crush the tablet.

Ivacaftor must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • kidney disease
  • liver disease
Let your doctor know if you are pregnant or breastfeeding.

Some genetic traits can affect your response to this medicine. Your doctor may need to perform genetic testing to know if this medicine is suitable for you.

For as long as you are taking this medicine, your doctor may need to perform blood tests to make sure that your liver and lung function is normal before you take this medicine and thereafter depending on your doctor’s advise. He may also need to have your eyes checked regularly. Your doctor will advise you about how often you need to have this test.
What side effects could I experience?
Ivacaftor may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects may include any of the following: headache, diarrhoea, rash, runny nose, ear pain and discomfort, common cold.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicine to treat fungal infection e.g. ketoconazole, fluconazole
  • medicine to treat TB (lung infection known as tuberculosis) e.g. rifampicin
  • medicine for epilepsy (fits or seizures) e.g. carbamazepine
  • medicine for heart disease e.g. digoxin
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin
This list does not include all medicines that may interact with Ivacaftor.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol and St John's wort.

Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).

Avoid Seville oranges.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on ivacaftor - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $139 a year.
Sign up for free
Already a member? Sign in