Antibacterial Resistance: Antibacterial drugs including Levofloxacin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Levofloxacin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and; increase the likelihood that bacteria will develop resistance and will not be treatable by Levofloxacin or other antibacterial drugs in the future.
Administration with Food, Fluids, and Concomitant Medications: Patients should be informed that Levofloxacin tablets may be taken with or without food. The tablet should be taken at the same time each day.
Patients should drink fluids liberally while taking Levofloxacin to avoid formation of a highly concentrated urine and crystal formation in the urine.
Antacids containing magnesium, or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc or didanosine should be taken at least two hours before or two hours after oral levofloxacin administration.