Mefenamic acid - oral

Patient Medicine Information
Why do I need this medicine?
Mefenamic acid helps relieve pain and inflammation associated with rheumatoid arthritis (inflammation in joints of fingers, wrist, feet, ankles) and osteoarthritis (joint pain or swelling disorder).

It may also be used to relieve pain associated with headache, menstrual period, dental work and surgery.

This medicine may be used to treat other conditions as decided by your doctor.
How do I take this medicine?
Take Mefenamic acid exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take it together with food or immediately after a meal.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the dose and course of your treatment depending on your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Mefenamic acid, other similar medicines for pain and inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin.

Alert your doctor if you have the following conditions:
  • active stomach ulcer or bleeding
  • history of stomach bleeding or perforation that is related to previous NSAID therapy
  • inflammation of the bowel (large or small intestines)
  • severe heart failure
  • severe liver disease
  • serious kidney disease
as Mefenamic acid may not be suitable for you.

This medicine should not be used to treat pain before or after a coronary artery bypass graft surgery (procedure to improve and restore the blood flow in the heart).

Do not take this medicine if you are on your 3rd trimester of pregnancy. This medicine may cause harm to your unborn child. You may wish to discuss alternative pain reliever with your doctor.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • risk factors for heart disease (e.g. high blood pressure, diabetes, high cholesterol levels in the blood, smoking)
  • liver disease
  • kidney disease
  • low volume of circulating blood in the body
  • dehydration
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Mefenamic acid to an elderly. Elderly may be more sensitive to the side effects.

If you are going for an operation, including minor surgery or dental work, inform your doctor or dentist that you are taking Mefenamic acid.

Avoid long-term use of any painkillers.

For as long as you are taking this medicine, you may need to have regular blood tests (e.g. complete blood count, liver and kidney function test) to check your body’s response to the medicine. Your doctor will advise you about how often you need to have these tests.

Your blood pressure may rise to unsafe levels without you noticing it. Routine monitoring of your blood pressure may be needed while you are being treated with this medicine.
What side effects could I experience?
Mefenamic acid may cause drowsiness, dizziness or blurred vision. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, diarrhoea, nausea, vomiting, stomach pain, constipation, indigestion, stomach wind, heartburn (food or acid from your stomach backs up into your mouth, leaving a sour or bitter taste), ringing in the ears, nervousness, swelling of the ankles, feet or hand.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever
  • pass out blood or black, tarry stools or vomit coffee-ground-like vomitus
  • unusual bleeding or bruising
  • yellowing of the skin or eyes
  • fever, chills, persistent sore throat or mouth ulcers
  • fast or irregular heartbeat
If you develop rashes, breathlessness, swollen mouth or eyes, stop taking Mefenamic acid and inform your doctor quickly. These could be signs of an allergic reaction.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • lithium (medicine to treat depression)
  • blood-thinning medicines e.g. aspirin, warfarin
  • medicines used in organ transplant or certain immune disorders e.g. tacrolimus, ciclosporin
  • medicines for high blood pressure or heart disease e.g. captopril, losartan
  • medicines for water retention (water pills) e.g. furosemide, hydrochlorothiazide
  • methotrexate (medicine to treat arthritis or cancer)
This list does not include all medicines that may interact with Mefenamic acid.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on mefenamic acid - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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