Metoprolol + hydrochlorothiazide - oral

Patient Medicine Information
Why do I need this medicine?
Metoprolol and Hydrochlorothiazide are combined in this medicine.

This medicine helps to keep your blood pressure under control.
How do I take this medicine?
Take Metoprolol + Hydrochlorothiazide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Ask your doctor or pharmacist about whether you should take this medicine with or without food. Different brands of this medicine may be taken differently.

Try to take it at the same time each day.

Metoprolol + Hydrochlorothiazide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it suddenly as this may worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • 2nd- or 3rd-degree heart block
  • severely slow heartbeat
  • abnormal heart rhythms due to problems with your heart's natural pacemaker
  • heart failure or weak heart
  • severe poor blood circulation to the arms or legs
  • inability to pass urine
as Metoprolol + Hydrochlorothiazide may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • 1st-degree heart block
  • low volume of fluid in the blood
  • narrowing of the blood vessels supplying the arms and legs
  • Raynaud’s disease (poor blood circulation which makes the toes and fingers numb and pale when feeling cold or stressed)
  • bronchospasm (breathing distress caused by tightening and narrowing of the airways)
  • thyroid disease
  • diabetes
  • personal or family history of gout (high uric acid level in the blood)
  • high levels of cholesterol in the blood
  • muscle weakness disorder
  • history of severe allergic reaction to allergens
  • high calcium levels in the blood
  • kidney disease
  • liver disease
Let your doctor know if you are pregnant or breastfeeding.

If you are going to have certain laboratory tests or an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking Metoprolol + Hydrochlorothiazide.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure during treatment.
  • Routine monitoring of heart rate, kidney function, fluid and electrolyte levels may be done while you are being treated with this medicine.
Your doctor will advise you about how often you need to have these tests.

What lifestyle changes can I make to improve my blood pressure?

Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.
What side effects could I experience?
Metoprolol + Hydrochlorothiazide may cause any of the following side effects: blurred vision, nausea, vomiting, diarrhoea, constipation, drowsiness, dizziness, headache, sweating, dry mouth, and skin rash.

This medicine may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • mood changes, muscle pain or weakness, loss of strength and energy
  • abnormal heartbeat
  • change in amount of urine passed
  • chest pain
  • skin lumps or changes
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines to treat depression e.g. fluoxetine, paroxetine, bupropion
  • medicines for mood disorders e.g. thioridazine, lithium
  • medicines for irregular heartbeat e.g. quinidine, propafenone
  • medicines for HIV infection e.g. ritonavir
  • cholesterol-lowering medicines e.g. colestyramine, colestipol
  • diphenhydramine (medicine for cold or allergy)
  • medicines to treat fungal infection e.g. terbinafine
  • cimetidine (medicine for gastric ulcer)
  • other medicines for high blood pressure e.g. reserpine, methyldopa
  • anti-inflammatory medicines
  • tubocurarine (muscle relaxant used during surgery)
  • medicines used to block pain and sensation
  • NSAIDs (medicine for pain and inflammation)
This list does not include all medicines that may interact with Metoprolol + Hydrochlorothiazide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Discuss with your doctor or dietitian about ways to cut down on your salt intake.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on metoprolol + hydrochlorothiazide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $139 a year.
Sign up for free
Already a member? Sign in