Closely monitor patients w/ chronic lung function impairment, especially asthma, for risk of hypersensitivity. Potential risk of cross sensitivity reactions w/ sulphasalazine. Severe photosensitivity reactions in patients w/ pre-existing skin conditions eg, atopic dermatitis & eczema. Perform haematological investigations if patient develops unexplained bleeding, bruising, purpura, anaemia, fever or sore throat. Terminate treatment if there is blood dyscrasia suspicion. Patients w/ conditions predisposing to myo- or pericarditis development. W/draw promptly if acute intolerance syndrome is suspected. Increased liver enzyme levels. May delay onset of action by organic or functional obstruction in the upper GIT. Nephrolithiasis; ensure adequate fluid intake during treatment. Patients w/ confirmed mild to moderate renal impairment. Evaluate renal function prior to initiation of therapy & at least twice a yr, while on treatment. Hepatic impairment. Pregnancy & lactation. Not recommended in childn <18 yr.