Adult: Initially, 2.5 mg 2-3 times daily, adjusted gradually according to response at weekly intervals, up to 10 mg tid. Last dose of the day should not be taken after evening meal or <4 hr before bedtime to reduce potential for supine HTN.
Initially, 2.5 mg 2-3 times daily, gradually increased as tolerated.
Description: Midodrine, a direct-acting sympathomimetic amine, is a prodrug which forms an active metabolite, desglymidodrine. It selectively activates the α1-adrenergic receptors of the arteriolar and venous vasculature, producing peripheral vasoconstriction and elevation of BP. Onset: Approx 1 hr. Duration: 2-3 hr. Pharmacokinetics: Absorption: Well absorbed from the GI tract. Bioavailability: 93% (desglymidodrine). Time to peak plasma concentration: 30 min (midodrine); 1-2 hr (desglymidodrine). Distribution: Poorly crosses the blood brain barrier. Plasma protein binding: <30%. Metabolism: Metabolised in the liver and other tissues. Undergoes rapid deglycination into its active metabolite, desglymidodrine. Excretion: Via urine (80% as desglymidodrine). Elimination half-life: 25 min (midodrine); approx 3-4 hr (desglymidodrine).
Store between 20-25˚C. Protect from light and moisture.
C01CA17 - midodrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
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