Montelukast sodium should be taken once daily. For asthma, the dose should be taken in the evening. Patient with asthma should take only one tablet daily in the evening.
Adults 15 years of age and older with asthma: The dosage for adults 15 years of age and older is one 10mg tablet daily.
Pediatric patients 6 to 14 years of age with asthma: The dosage for pediatric patients 6 to 14 years of age is one 5-mg chewable tablet daily.
Pediatric patients 2 to 5 years of age with asthma: The dosage for pediatric patients 2 to 5 years of age is one 4-mg chewable tablet daily.
General recommendations: The therapeutic of Montelukast Sodium on parameters of asthma control occurs within one day. Montelukast Sodium tablets and chewable tablets can be taken with or without food. Patients should be advised to continue taking Montelukast Sodium while their asthma is controlled, as well as during periods of worsening asthma.
No dosage adjustment is necessary for pediatric patients, the elderly, for patients with renal insufficiency, or mild-to-moderate hepatic impairment, or for patients of either gender.
Therapy with Montelukast Sodium in relation to other treatments for asthma: Montelukast Sodium can be added to a patients existing treatment regimen.
Reduction in Concomitant Therapy: Bronchodilator treatments: Montelukast sodium can be added to the treatment regimen of patients who are not adequately controlled on bronchodilator alone. When a clinical response is evident (usually after the first dose), the patients bronchodilator can be reduced as tolerated.
Inhaled Corticosteroids: Treatment with Montelukast Sodium provides additional clinical benefit to patients treated with inhaled corticosteroids. A reduction in the corticosteroid dose can be made as tolerated. The dose should be reduced gradually with medical supervision. In some patients, the dose of inhaled corticosteroids can be tapered off completely. Montelukast Sodium should not be abruptly substituted for inhaled corticosteroids.