Concise Prescribing Info
Amoxicillin trihydrate
Upper & lower resp tract, GIT, GUT, skin & soft tissue, biliary tract, bone & pelvic infections; gonorrhoea (non-penicillinase producting strains); septicaemia; endocarditis; meningitis; peritonitis; dental abscess (as an adjunct to surgical management). H. pylori eradication in PUD (duodenal & gastric). Prophylaxis of endocarditis.
Dosage/Direction for Use
Adult (including elderly) 250 mg tds, increasing to 500 mg tds for more severe infections. Severe or recurrent purulent infection of the resp tract 3 g bd. Simple acute UTI 2 3-g doses w/ 10-12 hr between doses. Dental abscess 2 3-g doses w/ 8 hr between doses. Gonorrhoea Single 3 g dose. H. pylori eradication in PUD (duodenal & gastric) Recommended at a dose of bd in association w/ a proton pump inhibitor & antimicrobial agents: Omeprazole 40 mg daily, amoxicillin 1 g bd, clarithromycin 500 mg bd for 7 days; or omeprazole 40 mg daily, amoxicillin 750 mg to 1 g bd, metronidazole 400 mg tds for 7 days. Childn up to 10 yr 125 mg tds, increasing to 250 mg tds for more severe infections; 3-10 yr Severe or recurrent otitis media 750 mg bd for 2 days, may be used as alternative course of treatment. Renal impairment in adult & childn >40 kg: Moderate (CrCl 10-30 mL/min) Max: 500 mg bd, Severe (CrCl <10 mL/min) Max: 500 mg daily. Childn <40 kg: Moderate (CrCl 10-30 mL/min) 15 mg/kg bd, max: 500 bd, Severe (CrCl <10 mL/min) 15 mg/kg once daily, max: 500 mg daily. Patient receiving peritoneal dialysis Severe renal impairment dosing. Patient receiving hemodialysis Severe renal impairment dosing. May administer an additional dose (500 mg for adult or 15 mg/kg for childn <40 kg) during & at the end of each dialysis. Prophylaxis of endocarditis Individualized dosage.
May be taken with or without food: May be taken w/ meals for better absorption & to reduce GI discomfort.
Hypersensitivity to penicillins. Possible cross-sensitivity w/ other β-lactam antibiotics (eg, cephalosporins).
Special Precautions
Discontinue therapy if an allergic reaction occurs. Risk for erythematous rashes associated w/ glandular fever. Prolonged use may result in overgrowth of non-susceptible organisms. Crystalluria. Maintain adequate fluid intake & urinary output. Renal impairment. Pregnancy & lactation.
Adverse Reactions
Drug Interactions
May increase incidence of rash & other allergic skin reactions w/ allopurinol. Prolonged prothrombin time w/ anticoagulants. May lower oestrogen reabsorption & reduce efficacy of combined OCs. May decrease renal tubular secretion w/ probenecid. False positive readings w/ chemical methods.
MIMS Class
ATC Classification
J01CA04 - amoxicillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections.
Moxilen cap 250 mg
100 × 10's
Moxilen cap 500 mg
100 × 10's
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