Hypothyroidism, raised intracranial pressure, hypotension w/ hypovolaemia, biliary tract disorder, pancreatitis; severe cor pulmonale
, severe bronchial asthma, severe chronic obstructive lung disease; inflammatory bowel disorders, prostatic hypertrophy, adrenocortical insufficiency; resp depression, renal/hepatic disease; 24 hr prior to cordotomy or other pain relieving surgery; abdominal surgery, prior substance abuse, tolerance & physical dependence may develop. Avoid abrupt cessation of prolonged use & therapy. History of epilepsy. May impair ability to drive or operate machinery. Elderly.