The adverse experiences listed as follows are classified by body system according to their incidence (common or uncommon). Common ADE have an incidence of ≥1% and uncommon ADE have an incidence of <1%.
Gastrointestinal: Common: Abdominal pain, anorexia, constipation, dry mouth, dyspepsia, nausea, vomiting. Uncommon: Elevated hepatic enzymes, biliary pain, ileus, taste perversion.
Central Nervous System: Common: Asthenia, confusion, headache, insomia, involuntary muscle contractions, somnolence, thought abnormalities. Uncommon: Agitation, dysphoria, euphoria, hallucinations, malaise, mood changes, paresthesia, respiratory depression, seizure, vertigo, vision abnormalities, withdrawal syndrome.
Genitourinary: Uncommon: Amenorrhea, decreased libido, impotence, urinary retention.
Cardiovascular: Uncommon: Hypotension, syncope.
Metabolic and Nutritional: Uncommon: Peripheral and pulmonary edema.
Respiratory: Common: Bronchospasm, decreased cough.
Dermatological: Common: Rash. Uncommon: Urticaria.
General: Common: Chills, pruritus, sweating. Uncommon: Allergic reaction, anaphylactic/anaphylactoid reactions, drug dependence, facial flushing, hypertonia, miosis, tolerance.
When nausea and vomiting are troublesome, MST Continus tablets can be readily combined with antiemetics. If constipation occurs, it may be treated with appropriate laxatives.