Per 10 mL Gadobenic acid 3,340 mg (5 mmol) as dimeglumine salt
Indications/Uses
Diagnostic liver MRI for the detection of focal liver lesions in patients w/ known or suspected primary liver cancer or metastatic disease; brain & spine MRI where it improves detection of lesions & provides diagnostic information additional to that obtained w/ unenhanced MRI; breast MRI for the detection of malignant lesions in patients where breast cancer is known or suspected on the basis of previous mammography or ultrasound results. Contrast-enhanced MR-angiography where it improves the diagnostic accuracy for detecting clinically significant steno-occlusive vascular disease in patients w/ suspected or known vascular disease of the abdominal or peripheral disease.
Closely supervise patients for 15 min following inj. Patients w/ CV disease; suffering from epilepsy or brain lesions; history of asthma or other allergic disorders. Do not use in patients w/ history of sensitivity to benzyl alcohol. As w/ other other gadolinium-chelates, contrast-enhanced MRI ashould not be performed w/in 7 hr of MultiHance-enhanced MRI exam. Avoid local extravasation during IV administration. Use the lowest effective dose & perform risk assessment before administering repeated doses. Screen patients for renal dysfunction (obtain laboratory tests) prior to administration. Avoid in patients w/ severe renal impairment & peri-op liver transplantation. Pregnancy & lactation. Not recommended in childn <2 yr (brain & spine MRI), <18 yr (liver & breast MRI, MRA). Elderly (≥65 yr).
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