Special Instructions for Use, Handling and Disposal: Avoid vigorous shaking.
The solution should be visually inspected prior to use. Only clear solutions without particles should be used.
Filgrastim vials and syringes are for single use only.
Instructions for dilution: If required, filgrastim may be diluted in 5% glucose. Dilution to a final concentration less than 5 mcg/per ml is not recommended at any time.
For patients treated with Neupogen diluted to concentrations below 1.5 MU (15 μg) per ml, human serum albumin (HSA) should be added to a final concentration of 2 mg/ml.
Example: In a final injection volume of 20 ml, total doses of filgrastim less than 30 MU (300 μg) should be given with 0.2 ml of 20% human albumin solution Ph. Eur. added.
Diluted Neupogen solutions should not be prepared more than 24 hours before administration and should also be stored refrigerated at 2 - 8ºC.
Disposal of Unused/Expired Medicines: The release of pharmaceuticals in the environment should be minimized. Medicines should not be disposed of via wastewater and disposal through household waste should be avoided. Use established "collection systems", if available in the patient's location.
Incompatibilities: Neupogen should not be diluted with saline solutions. If required, Neupogen may be diluted in 5% glucose.
Diluted Neupogen may be adsorbed to glass and plastic materials. However, when diluted in 5% glucose solution, Neupogen is compatible with glass and a variety of plastic including PCV, polyolefin (a co-polymer of polypropylene and polyethylene) and polypropylene.
Neupogen vials and pre-filled syringes are for single-dose only.