Active Ingredient: filgrastim (recombinant-methionyl human granulocyte-colony stimulating factor, r-metHuG-CSF, from E. coli K12).
Filgrastim is a highly purified non-glycosylated protein comprising 175 amino acids. Filgrastim is produced in a laboratory strain of Escherichia coli bacteria which has been genetically altered by the addition of a gene for the granulocyte colony-stimulating factor.
Vials: 1 vial of Neupogen of 1.0 ml injection solution contains 30 MU (= 300 μg) of filgrastim.
1 vial of Neupogen of 1.6 ml injection solution contains 48 MU (= 480 μg) of filgrastim.
Pre-filled syringes: 1 pre-filled syringe of Neupogen of 0.5 ml contains 30 MU (= 300 μg) of filgrastim.
1 pre-filled syringe of Neupogen of 0.5 ml contains 48 MU (= 480 μg) of filgrastim.
Excipients/Inactive Ingredients: sodium acetate*, sorbitol, polysorbate 80, water for injection.
*Sodium acetate is formed by titrating glacial acetic acid with sodium hydroxide.