Novatretin Dosage/Direction for Use





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Full Prescribing Info
Dosage/Direction for Use
Because there are differences in the absorption and rate of metabolism of acitretin, the dosage must be individually adjusted. NOVATRETIN capsules are to be taken orally and should be swallowed whole with a glass of water or milk.
Adults: The initial daily dosage, 25 mg (i.e. 1 capsule 25 mg) or 30 mg (i.e. 3 capsules 10 mg) for about 2-4 weeks may give satisfactory therapeutic results.
The maintenance dose must be based on clinical efficacy and tolerability. In general, a daily dosage of 25-50 mg taken for a further 6-8 weeks achieves optimal therapeutic results.
It may be necessary in some cases to increase the dose up to a maximum of 75 mg/day (i.e. 3 capsules 25 mg).
Therapy can be terminated in patients with psoriasis whose lesions have resolved sufficiently. Relapses should be treated as described previously.
In disorders of keratinization, maintenance therapy is usually needed, though the lowest possible dosage should be given. This may be less than 20 mg/day and should not exceed 50 mg/day.
Children: In view of possible severe side effects associated with long-term treatment, the risk should be carefully weighed against the therapeutic benefit. Acitretin should be used only when all alternative therapies have proved inadequate.
The dosage should be established according to bodyweight. The daily dosage is about 0.5 mg/kg. Higher doses (up to 1 mg/kg daily) may be necessary in some cases for limited periods, but only up to a maximum of 35 mg/day. The maintenance dose should be kept as low as possible in view of possible long-term side effects.
Combination treatment: When acitretin is used in combination with other types of therapy, it may be possible - depending on the patient's individual response - to reduce the dosage of acitretin.
Standard topical treatments can generally be continued and do not interfere with acitretin.
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